To test the feasibility of our hypothesis, we detected the effects of DHM on the differentiation, proliferation, and migration of primary fibroblasts from the lungs of IPF patients and control subjects or those from mice, and to explore whether the STAT3/p-STAT3/GLUT1 signaling pathway is involved in these effects, we also used bleomycin (BLM) to induce pulmonary fibrosis in male mice and confirmed the effects of DHM in the mouse model. This evidence concerns the gene STAT3 and idiopathic pulmonary fibrosis.