ABCB8 and cancer: Interestingly, DOX cardiotoxicity is associated with cardiac iron accumulation and dose-dependent depletion of ABCB8 (Miranda et al., 2003; Ichikawa et al., 2014; Mouli et al., 2015), whereas DOX resistance in cancer is commonly associated with ABCB8 overexpression and unchanged or deficient cellular iron (Elliott and Al-Hajj, 2009; Chekhun et al., 2013; Basu et al., 2017; Bajbouj et al., 2019).