The mitochondrial exporter, ABCB8, is frequently up-regulated in DOX-resistant cancers, and correcting ABCB8 expression restores sensitivity to DOX (Gillet et al., 2004; Elliott and Al-Hajj, 2009; Basu et al., 2017; Wen et al., 2018). The gene discussed is ABCB8; the disease is cancer.