ERK signaling is associated with ferroptosis in many cancers, including multiple myeloma (Chen J. et al., 2021), endometrial carcinoma (Qin et al., 2021), hepatocellular carcinoma (Fei et al., 2021), and pancreatic cancer (Ye et al., 2020). The gene discussed is MAPK1; the disease is endometrial carcinoma.