ERK signaling is associated with ferroptosis in many cancers, including multiple myeloma (Chen J. et al., 2021), endometrial carcinoma (Qin et al., 2021), hepatocellular carcinoma (Fei et al., 2021), and pancreatic cancer (Ye et al., 2020). Here, MAPK1 is linked to familial pancreatic carcinoma.