In different study, Odunsi and colleagues utilized NSG-HHD/SGM3 (N-HSGM3) mice model to test the efficacy of combined immune checkpoint blockers (ICBs) such as anti-PD1/anti-CTLA4 antibodies in combination with adoptively transferred autologous tumor-associated leukocytes/tumor-infiltrating lymphocytes (TALs/TILs) or PBMCs in patient-derived ovarian cancer xenografts. The gene discussed is CTLA4; the disease is ovarian carcinoma.