Analysis of HERV-K (HML-2) gag, pol, and env gene transcription in lung cancers showed that the transcriptional levels of gag, pol, and env mRNA were significantly higher in SCLC, adenocarcinoma, squamous cell carcinoma, and large cell carcinoma than in healthy controls (Figures 3D–F). This evidence concerns the gene ERVW-1 and large cell carcinoma.