In coincidence with flow cytometry results, HCMV infection induced the increment of p53, Bax, cytochrome c, GRP78, and CHOP, and the decrement of Bcl-2, and Ru360 or siMCU dampened these apoptotic changes while spermine enhanced apoptosis (Figures 4E,F). This evidence concerns the gene BCL2 and cytomegalovirus infection.