Espinosa et al. (88) assessed the serum levels of haptoglobin and serum amyloid A, two inflammatory acute-phase proteins detected during the course of PTB infection, in 190 PTB naturally infected animals classified according to the different pathological forms associated with infection (59 uninfected animals without lesions, 73 with focal lesions, 19 with multifocal, 11 with diffuse paucibacillary, and 28 with diffuse multibacillary lesions). This evidence concerns the gene HP and infection.