More and more genes related to ferroptosis have been identified in glioma, such as ACSL4 that protects glioma cells and exerts antiproliferative effects by activating a ferroptosis pathway (14), ATF3 that contributes to brucine-induced glioma cell ferroptosis (15), and COPZ1 that manipulates NCOA4 to regulate the ferroptosis process in GBM (16). This evidence concerns the gene COPZ1 and central nervous system cancer.