It is worth noting that a few articles reported on more than one epilepsy gene.<h4>Conclusion</h4>DS is not only identified in variants of <i>SCN1A</i>, but other genes such as <i>PCDH19, SCN2A, SCN8A, SCN1B, GABRA1, GABRB3, GABRG2, KCNA2, CHD2, CPLX1, HCN1A, STXBP1</i> can also be involved in DS or DS-like phenotypes. The gene discussed is CPLX1; the disease is epilepsy.