AQP4 and Parkinson disease: In a study establishing an animal model of PD by administering 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, mutant mice lacking AQP4 were shown to be significantly more susceptible to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity than their wild-type littermates, confirming an important role for AQP4 in the process of MPTP neurotoxicity and suggesting that therapeutic strategies targeting astroglial modulation with AQP4 may offer great potential for the development of new therapies for PD (65).