Experiments confirmed that injection of fluorescent tracer into the stroke mouse model revealed a decrease in tracer drainage into the deep cervical lymph nodes and the influx into the brain parenchyma, further confirming impaired lymphatic drainage in stroke mice, and also observing the impaired function of astrocyte AQP4, leading to accumulation of Tau protein in the brain (88). The gene discussed is AQP4; the disease is Stroke.