Gliomas also show changes in several other genes, such as EGFR (epidermal growth factor receptor), P53, NF1 (neurofibromin 1), CDKN2A/B (cyclin-dependent 2A/B kinase inhibitor), and PTEN (phosphatase and tensin homolog, which inhibit the mTOR pathway). The gene discussed is PTEN; the disease is central nervous system cancer.