CASP3 and neoplasm: EI24 is a p53 and E2F target gene that inhibits tumor progression through attenuation of NF-κB signaling (Choi et al., 2013; Sung et al., 2013), while RERE protein colocalizes with the pro-apoptotic protein BAX and triggers caspase-3 activation (Waerner et al., 2001).