In fact, the filament-forming cytoskeletal GTPase SEPTIN2 and the MCM2 subunit of the replicative helicase complex (MCM complex), both well-documented CK2 substrates related to cell cycle progression, were down-phosphorylated in CIGB-300-treated AML cells (Rosales et al., 2021a). The gene discussed is SEPTIN2; the disease is acute myeloid leukemia.