SIRT1 and early-onset autosomal dominant Alzheimer disease: The expression of sirtuin 1 (SIRT1) is decreased in diseases of accelerated ageing including Alzheimer’s disease, chronic kidney disease, osteoporosis, T2D, metabolic syndrome, COPD, atherosclerosis, and cardiac failure (Nakamaru et al., 2009; Guarente and Franklin, 2011).