For example, it promotes atg4b-mediated autophagy and attenuates sorafenib sensitivity in hepatocellular carcinoma cells (Chen et al., 2021); it regulates eIF4A3/MUC1/EGFR signalling and modulates the response of EGFR-mutant lung cancer to EGFR tyrosine kinase inhibitor resistance (Takahashi et al., 2021). The gene discussed is ATG4B; the disease is lung cancer.