In a bleomycin-induced pulmonary fibrosis model, TRPC6-deficient mice show reduced production of collagen and an almost normal function of the respiratory system, which can be explained by the upregulation of TRPC6, increased calcium flow and localization of nuclear factor of activated T cells (NFAT) in wild-type primary murine lung fibroblasts (Hofmann et al., 2017). This evidence concerns the gene TRPC6 and pulmonary fibrosis.