In the p48-Cre; LSL-Kras(G12D); Trp53 (flox/+) (KPC) mouse model of human pancreatic ductal adenocarcinoma (PDAC), FAK inhibition can downregulate the fibrosis with a decrease in collagen deposition, fibroblasts, and α-SMA production, and without an acceleration of tumor progression (Jiang et al., 2016). This evidence concerns the gene PTK2 and neoplasm.