Using an adenovirus to overexpress miR-27b-3p was observed to reduce the duration of AF, ameliorate atrial fibrosis, increase connexin 43 expression and decrease the expression of type I/III collagen, α-SMA, TGFβ1, Wnt3a and p-β-Catenin, indicating that miR-27b-3p regulates the Wnt/β-catenin signaling pathway by targeting Wnt3a (Lv et al., 2019). This evidence concerns the gene GJA1 and atrial fibrillation.