Increased expression of αvβ3 or αvβ5 integrins is observed in the dermis of scleroderma patients (Hinchcliff and O’Reilly, 2020), and these integrins induce autocrine TGFβ signaling in patient fibroblasts in vitro (Santos and Lagares, 2018), suggesting that αvβ3/5-mediated TGFβ activation could be important under pathological conditions (Brown and Marshall, 2019). Here, TGFB1 is linked to scleroderma.