In a pressure overloading-induced cardiac hypertrophy mouse model, administration of the DNMT inhibitor RG108 was found to diminish the fibrotic response and downregulated a set of genes, including Atp2a2 (encodes one of the SERCA calcium-ATPases) and Adrb1 (encodes the β1-adrenoceptor) (Stenzig et al., 2018). Here, DNMT1 is linked to cardiac hypertrophy.