Administration of MC1568, a selective class IIa HDACI, suppresses the expression of α-SMA, fibronectin, and type I collagen, reduces the phosphorylation of Smad3 and NF-κB, and induces the production of ɑvβ6 integrin, suggesting that it alleviates renal fibrosis by inhibiting the TGFβ1-induced response and promoting antifibrotic protein production (Xiong et al., 2019). Here, TGFB1 is linked to renal fibrosis.