Notably in the LHb, eCB signaling plays a role in controlling synaptic plasticity, neuronal activity, and subsequent associated behavior, therefore alterations in eCB regulation of LHb neurons contribute to LHb dysfunction that is associated with motivational and social deficits seen in depression and stress-related disorders (Shepard and Nugent, 2021). The gene discussed is LHB; the disease is depressive disorder.