YY1 can regulate glucose uptake, pentose phosphate pathway, and lipid metabolism of tumor cells by regulating peroxisome proliferator-activated receptor gamma coactivator-1 β (PGC-1β) [20], a key enzyme of lipid metabolism, and glucose-6-phosphatedehydrogenase (G6PD) [21], which regulates the key rate-limiting enzymes of glucose metabolism, that leads to metabolic reprogramming of tumor cells to promote tumor cell growth and metabolism. The gene discussed is YY1; the disease is neoplasm.