While TSC1/2 and DEPDC5 directly regulate the mTOR pathway, other neurodevelopmental disorder genes such as cyclin-dependent kinase-like 5 (CDKL5), ubiquitin-protein ligase E3A (UBE3A), and methyl CpG binding protein (MECP2) are also known to affect or be affected by the mTOR signaling. The gene discussed is UBE3A; the disease is neurodevelopmental disorder.