Six in-frame deletions in SCN1A were identified in our cases with SMEI, generalized epilepsy with febrile seizures plus (GEFS+), partial epilepsy with febrile seizures plus (PEFS+) and Lennox–Gastaut syndrome (LGS) (Table 1). Here, SCN1A is linked to Febrile seizure (within the age range of 3 months to 6 years).