The phenotypic spectrum observed for GABRG2 variants, ranging from febrile seizures to epileptic encephalopathy, is similar to those of the other GABAA receptor genes GABRA1, GABRB2, and GABRB3 (Johannesen et al., 2016; Moller et al., 2017; Yang et al., 2020, 2021). Here, GABRB2 is linked to Epileptic encephalopathy.