BDNF and Alzheimer disease: Guo et al. (2018) found an increased level of BDNF-AS and a reduced expression of BDNF, accompanied by enhanced apoptosis induction and decreased cell viability in an AD cell model established by Aβ25–35 exposure to PC12 cells. They also demonstrated that BDNF-AS silencing had crucial beneficial effects on enhancing cell viability, and suppressing oxidative stress and apoptosis through negative modulation of BDNF. Ding et al. (2021) uncovered an elevated expression of BDNF-AS in the peripheral blood of AD patients.