Xu et al. (2018) indicated that lncRNA-p21 stimulated cellular apoptosis and suppressed cell viability by sponging miR-1277-5p and indirectly enhancing α-synuclein level in PD. The transient receptor melastatin 2 (TRPM2) is a non-selective Ca2+ osmotic channel elevated in PD brains (Belrose and Jackson, 2018). It has been found that lncRNA-p21-miR-625-TRPM2 axis has pivotal effects in oxidative stress and neuroinflammation in PD models (Ding et al., 2019). Here, TRPM2 is linked to Parkinson disease.