Liu et al. (2017) found a reversed expression between MALAT1 and miR-124 in MPTP-induced PD mice. Further mechanistic studies showed that MALAT1 promoted apoptosis by interacting with miR-124 and negatively modulating its expression. Zhang et al. (2016) proved that MALAT1 could increase the expression of a-synuclein protein by binding with it to enhance the stability. Besides, Chen et al. (2018) revealed elevated levels of MALAT1 and LRRK2, and decreased expression of miR-205-5p in MPTP-induced PD mice. This evidence concerns the gene LRRK2 and Parkinson disease.