HOTAIR and Parkinson disease: Lin et al. (2019) indicated the function of the cellular HOTAIR/miR-126-5p/RAB3IP signaling pathway in PD. NOD-like receptor family pyrin domain containing 3 (NLRP3) is a prominent inflammasome in immune system and contributes to several disease. HOTAIR targeted miR-326 to promote the neuronal injury through facilitating NLRP3 mediated apoptosis in PD (Zhang et al., 2021). Additionally, Lang et al. (2020) explored that HOTAIR enhanced neuronal pentraxin II (NPTX2) through targeting miR-221-3p, thereby driving autophagy in PD mouse models.