BACE1 and Alzheimer disease: Mus et al. (2007) proved that BC200 RNA expression was markedly specific increased in AD brains. They also indicated that elevated BC200 levels was paralleled with the severity of AD. In addition, studies have shown that BC200 upregulation directly promote BACE1 level and impair cell viability subsequently, thereby increasing Aβ42 expression (Feng et al., 2018; Li et al., 2018).