SOX2-OT and Alzheimer disease: Arisi et al. (2011) revealed that SOX2OT reduces neurogenesis by mediating SOX2 gene expression in AD. It has been proved that abnormal expression or activation of 10–11 translocation-2 (TET2) is closely associated with AD (Carrillo-Jimenez et al., 2019). Li L. et al. (2021) demonstrated that TET2 was involved in neuron formation via modulating several lncRNAs (SOX2OT, MALAT1, etc.).