Concurrent immunohistochemical analysis of hippocampal sections confirmed characteristic distribution tau phosphorylated at positions relevant to AD [CP13 (pS202) and PHF1 (pS396/pS404); (Andorfer et al., 2003)] in the CA1 and CA3 in 8-month-old htau animals (Supplementary Figure 1). This evidence concerns the gene MAPT and Alzheimer disease.