MAPT and Alzheimer disease: Similar to human AD patients the majority of tau pathology in htau mice is found in the neocortex and hippocampus (Andorfer et al., 2003; Polydoro et al., 2009) and exhibits phosphorylation of key serine residues (S202 and S396) as early as 3 months in these regions (Neddens et al., 2020).