APP and Alzheimer disease: Previously, bioenergetic assessments of synaptosomes from commonly used mouse models with AD-like phenotypes revealed no consistent bioenergetic deficiencies from three models [J20 age 6 months, Tg2576 age 16 months, APP/PS age 9 months (Choi et al., 2012)], suggesting the intrinsic energetic capacity of synaptosomes were maintained in these symptomatic AD mouse models.