MAPT and Alzheimer disease: Notably, precise mechanisms by which the ε4 allele increases AD risk are currently controversial, however, the ε4 allele is associated with enhanced oxidative stress, more severe amyloid pathology (Holtzman et al., 2012), disruption of neuronal signaling, and—most relevant to our study—altered phosphorylation of tau and promotion of NFT formation (Posse De Chaves and Narayanaswami, 2008; Shi et al., 2017).