One study investigating aberrant interactions of tau with the mitochondrial fission protein Drp1, reported increased mitochondrial fission and fission linked-GTPase activity from post-mortem AD patient samples and in the APP, APP/PS1, 3xTG.AD mouse models (Manczak et al., 2011; Manczak and Reddy, 2012). This evidence concerns the gene APP and Alzheimer disease.