TNF and hypertensive disorder: However, in patients with SARS-CoV-2 infection, hypertension could potentially exacerbate the inflammatory profile indicating that hypertension raises the chance of a more severe illness as these patients have greater levels of inflammatory biomarkers including tumor necrosis-α (TNF-α) and interleukin-6 (IL-6) contributing to endothelial dysfunction and oxidative stress confirming a possible pathophysiological link between hypertension and COVID-19 [12, 23].