Based on previous data showing elevated expression of Kv3.4 aroundAβ plaques in human AD brain and in model systems (Angulo et al., 2004; Boscia et al.,2017; Pannaccione et al., 2007), here we tested the hypothesis thatKv3.4 is involved in synapse loss in the APP/PS1 mouse model ofamyloidopathy. This evidence concerns the gene KCNC4 and Alzheimer disease.