TNF and neoplasm: In our study, the oncogenic inflammatory pathways including Wnt, TNF, T cell receptor identified by PANTHER and ShinyGO v0.61 analysis in Rb tumors are reported to induce apoptosis in Rb tumor cells (Cullinan and Brandt 2003; Hackam 2006; Mitra et al., 2012; Andersch et al., 2019).