However, the fascinating observation of our study is that the hub genes including CDK1, CDK2, CCNB1, and HDAC1 and common genes including E2F3 identified in Rb tissues are well-known oncogenes that trigger cell cycle progression in tumor cells in the absence of RB1 gene (Cerqueira et al., 2007; Chenette 2010; Madhavan et al., 2009) (Ye et al., 2017) (Brehm et al., 1998). Here, E2F3 is linked to neoplasm.