To summarize, the integrative bioinformatics analysis has identified ten hub genes including CDK1, CDK2, CCNB1, CUL1, RB1, TP53, HDAC1, JUN, PIK3CA, and MAPK1 and three common genes including E2F3, ESR1 and UNC5D in Rb tumors. The gene discussed is CDK2; the disease is retinoblastoma.