To summarize, the integrative bioinformatics analysis has identified ten hub genes including CDK1, CDK2, CCNB1, CUL1, RB1, TP53, HDAC1, JUN, PIK3CA, and MAPK1 and three common genes including E2F3, ESR1 and UNC5D in Rb tumors. This evidence concerns the gene CUL1 and retinoblastoma.