RB1 and cancer: Unlike routine integrative bioinformatics analysis that involves the combination of two major domains like gene expression profiles/epigenetic profile, genome profile/clinical profile, etc.(Yang et al., 2017; Zhang et al., 2019; Jin 2020), we for the first time have integrated three major domains of cancer biology including, DNA methylation, gene and microRNA expression to precisely predict the target proteins with the potential to serve as promising early diagnostic biomarkers of Rb.