However, in this study, UNC5D gene expression is found to be remarkably high in Y79 and WERI-Rb-1retinoblastoma cells when compared to that in hTERT-RPE cells and other cancer cell lines including HeLa (human cervical cancer cell line), HCT116 (human colon cancer cell line) and SH-SY5Y (human neuroblastoma cell line) (data not shown). Here, UNC5D is linked to malignant colon neoplasm.