IFNG and psoriasis: DiD-labeled native sEVs and IFNγ-sEVs were intradermally injected into the mice, and bioluminescent images of IFN-γ stimulated MSC-sEVs taken in vivo confirmed a marked accumulation of IFNγ-sEVs on the injured skin of IMQ-induced psoriasis-like mice, as compared to unstimulated native sEVs (Figure 3A).