IMQ-induced psoriasis-like mice were injected with phosphate-buffered saline (PBS), IFNγ-sEVs (25 mg/kg), ASO-210 (8 nmol), ASO-210&IFNγ-sEVs (8 nmol +25 mg/kg), or ASO-210@IFNγ-sEVs (8 nmol +25 mg/kg), intradermally 4 times from day 2 to day 5 to test the therapeutic effect (Figure 3B). The gene discussed is IFNG; the disease is psoriasis.