In prostate cancer cells, overexpression of Smad2/3 enhances aerobic glycolysis independently of TGF-β stimulation but requires PKCε-mediated phosphorylation of the Smad3 linker region, which assists binding of Smad3 to the promoter of glycolytic genes (Xu et al., 2018). The gene discussed is SMAD3; the disease is prostate carcinoma.