In addition, loss of the rate limiting enzyme Nsdhl (NAD(P)-dependent steroid dehydrogenase-like) involved in cholesterol synthesis in mouse pancreatic ductal adenocarcinoma cells activates Srebp1 (sterol regulatory element-binding protein 1), which enhances TGF-β1 expression and secretion and consequently facilitates EMT (Gabitova-Cornell et al., 2020). This evidence concerns the gene NSDHL and pancreatic ductal adenocarcinoma.