Stage et al. (2016) used elegant brain imaging to analyze the effect of the top 20 AD risk genes on gray-matter density and FDG PET brain metabolism By analyzing a cohort of 381 normal controls, 634 mild cognitive impairment (MCI) patients and 243 dementia patients, they determined that the RIN3 risk variant rs10498633 G/T was significantly associated with mean median temporal lobe grey matter density (GMD) (Stage et al., 2016). The RIN3 variant was also a significant predictor of hypometabolism in normal control group (Stage et al., 2016). Here, RIN3 is linked to Cognitive impairment.