In 2014, a genome-wide association case-control study of severe COPD was carried out; the results revealed that Rin3 rs754388 allele C was a risk allele [p = 5.25 × 10–9, OR = 1.28 (1.18–1.39)] (Cho et al., 2014). Here, RIN3 is linked to chronic obstructive pulmonary disease.