In a 2017 study of gene methylation profiling of blood and brain samples from 22 AD and 26 normal control subjects (27 males, 21 females), the AD samples showed significant group-wide hypomethylation of 7 CpGs located within the 3′UTR region of Rin3 (CpG1 p = 0.019, CpG2 p = 0.018, CpG3 p = 0.012, CpG4 p = 0.009, CpG5 p = 0.002, CpG6 p = 0.018, and CpG7 p = 0.013, respectively) (Boden et al., 2017). Here, RIN3 is linked to Alzheimer disease.