When comparing extreme AD cases with centenarian controls, the variant effect size for the SLC24A4/RIN3 SNP increased by 4.5-fold, versus 2-fold for APOE-ε4 and 6.5-fold for TREM2 (R74H) variant in comparison to published effect sizes (Tesi et al., 2019). This evidence concerns the gene APOE and Alzheimer disease.