For instance, particular SNPs such as the A118G have been linked to reduced sensitivity to opioid medication in the patient suffering from chronic pain (36, 37) and cancer (19) and even cancer recurrence in specific tumor types and populations (38, 39), Also, TLR4 gene polymorphisms have also been studied and may play a role in proliferation and differentiation and multiple isoforms of receptor subtype resulting from alternative splicing of the pre-mRNA transcript have been identified albeit their functional role has yet to be clarified (40). Here, TLR4 is linked to neoplasm.