As featured DEGs, CCL5, CCL19, CXCL9 and CXCL10 were overexpressed in claudin-low breast cancer cells and tissues which were positively correlated with tumor-infiltrating immune cells, especially CD8+T cells and macrophages, but CLDN8 and CLDN11 were repressed in claudin-low breast cancer cells and tissues. The gene discussed is CLDN8; the disease is breast cancer.