The TFs most commonly identified are related to fundamental processes of DNA modifications, which have been associated with cancer, chromatin remodeling, neurodegenerative diseases, and epigenetics, i.e., ATRX, ASCL2, ATOH8, BCL6, BTG2, C11orf65, CCDC148, CCDC88A, CDC6, CENPE, CEP170-2, CHD9, CLK4, CWC22, DGCR8, FOXP2, HFM1, HIST1H4K, HLTF, ID2, KIF20B, KBTBD8, LMX1B, LINGO1, MAFF, NAA16, PHF1, PPIG, RFX1-2, SLF1, STK36, YOD1, ZFY, and ZNF236 (Tables 2, 3). The gene discussed is CCDC148; the disease is cancer.