AKT1 and neoplasm: Some meta-analysis studies suggest that the mechanism of antiproliferation by statins is beneficial for cell survival and cancer-specific cell survival; however, the effect could be pleiotropic, affecting other mechanisms such as protein prenylation, tumor cell proliferation and migration, inhibiting Ras signaling, inducing apoptosis through inhibition of Akt phosphorylation, and consequently mTOR down-regulation at other cellular level (84).