CCN2 and cancer: In the STRING networks, the main clusters corresponded to the network C1 which is associates to the DEGs, FOS, FOSB, BTG2, EGR3, GADD45A, SGK1, and MAFF and interacts with the C6, C10, C11, and C12 clusters, containing DEGs such as DUSP1, DDIT3, BCL2, CTGF, and ATRX. A classification and frequency analysis of each DEG associated with cancer networks in some of the more frequent cancer types such as breast, gastric, and colorectal cancers, are shown (Figures 3C, D).