As shown in Table 5, PMR value of IL-6 promoter<54.91% (OR=10.243, 95% CI 5.455-19.233, P <0.001), AFP> 20 ng/ml (OR=4.689, 95% CI 2.568-8.563, P <0.001) and HBV-DNA positive (OR=3.754, 95% CI 1.956-7.208, P<0.001) were independent risk factors affecting the occurrence of HBV-associated HCC. Here, IL6 is linked to hepatocellular carcinoma.