We identified the innate anti-viral immunity gene APOBEC3G as a major H19 downstream gene (12, 13) and demonstrated that the downregulation of H19 or APOBEC3G by siRNA or the bioactive agent sulforaphane prevented H19-mediated PDAC progression features as demonstrated by assays for colony formation, migration, invasion, Smad2 phosphorylation and tumor xenograft growth (12). This evidence concerns the gene H19 and neoplasm.