Prostate-specific G-protein coupled receptor (PSGR) is overexpressed in prostate cancer (PC) cells and can spread to surrounding cells along with TDEs, thereby mediating the enrichment of mRNA in exosomes in EMT-related pathways and facilitating the migration, invasion, stem cell differentiation, and EMT of PC cells and normal prostate epithelial cells (51). The gene discussed is OR51E2; the disease is pachyonychia congenita.