Among them, HPDL, 4-hydroxyphenylpyruvate dioxygenase-like protein, a previously uncharacterized protein, localized in mitochondria, where it may function as 4-hydroxyphenylpyruvate dioxygenase, which was recently reported to be positively associated with the development of pancreatic ductal adenocarcinoma (PDAC) (36), AML (37), and breast cancer (38). Here, HPDL is linked to pancreatic ductal adenocarcinoma.