MiR-17 family members (such as miR-17-5p, miR-20a and miR-106a) are overexpressed in human progenitor cells and inhibit AML1(the leukemia-associated transcription factor acute myeloid leukemia 1; also known as runt-related transcription factor 1, or RUNX1), leading to downregulation of M-CSFR, which prevents differentiation and activity of tumor MDSCs (63). This evidence concerns the gene RUNX1 and neoplasm.