TYR and melanoma: Application of a proton beam turned out, consequently, to be an effective mode of therapy of melanotic tumors of the eye (uveal melanoma) (153, 154), and inhibition of melanogenesis (e.g., by the inhibition of tyrosinase activity via sequestration of copper) or increase in oxygen level became a promising way to sensitize melanoma tumors for radiotherapy (152, 155).