(67) established a link between the cytokine TRAIL (Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand) and NF-kB in LGLL by demonstrating increased TRAIL mRNA and protein in LGLL cells as well as increased soluble TRAIL in sera from LGLL patients compared to healthy controls (67). The gene discussed is TNFSF10; the disease is T-cell large granular lymphocyte leukemia.