The L5 proteins of 3 serotypes of adenovirus HAdV2, HAdV3, and HAdV5 are docked with the seven highly expressed pancreatic cancer receptors SLC2A1, MET, IL1RAP, NPR3, GABRP, SLC6A6, and TMPRSS4. Here, NPR3 is linked to familial pancreatic carcinoma.