To date, emerging regulatory axes involving lncRNA/miRNA/mRNA have been determined to be involved in glioma progression, such as H19/miR-138/HIF-1α (10), BCYRN1/miR-619-5p/UEDC2 (25), PVT1/miR-128-3p/GREM1 (26), and SNHG16/miR-373/EGFR (27). The gene discussed is PVT1; the disease is central nervous system cancer.