CD274 and thyroid gland undifferentiated (anaplastic) carcinoma: In addition, many lncRNAs also play a significant role in the regulation of immunity, such as lncRNA UCA1 attenuated the killing effect of cytotoxic CD8 + T cells on anaplastic thyroid carcinoma (ATC) cells through the miR-148a/PD-L1 pathway (28).