However, on the other hand, it leads to a decrease in malonyl-CoA and the synthesis of downstream PUFA, which in turn activates SREBP1c and upregulates the expression of glycerol-3-phosphate acyltransferase 1 (GPAT1) that catalyzes triglyceride synthesis, stimulating hepatic VLDL secretion and leading to hypertriglyceridemia (40). Here, SREBF1 is linked to hypertriglyceridemia.