It is worth noting that there are studies already confirmed that inhibiting ACCs in the liver by using ND-630 (GS-0976) can significantly reduce 29% liver fat, hepatic steatosis, and markers of liver injury in NAFLD patients (101, 102), which further encourage the finding of ACCs inhibitors for therapeutic proposes. The gene discussed is ACCS; the disease is metabolic dysfunction-associated steatotic liver disease.