However, the targeting strategy has to be selected carefully as it has been shown that the expression of nutrient transporters, such as GLUT1, in the intra-tumor microvasculature can differ between cancer subtypes, as it was shown by Yonemori et al. (2010) in brain metastases of triple negative and HER2/neu-positive breast cancers (209). This evidence concerns the gene ERBB2 and breast cancer.