From an immunohistochemical point of view, the two reported neoplasms expressed the hepatoid markers arginase-1, CD10, and Hep Par-1, and were also positive for some markers typically expressed in tumor types other than PDAC, such as β-catenin and LEF-1, classically positive and very specific for SPN [35, 36], and CD56, usually positive in neuroendocrine tumors, although without a high specificity. Here, LEF1 is linked to neuroendocrine neoplasm.