Other PNPLA enzymes actually exhibit different activities than PLA2, for example, PNPLA3 is actually a triacylglycerol lipase rather than a PLA2, and there is enormous interest in this enzyme currently because of its association with nonalcoholic fatty liver disease and its advanced form nonalcoholic steatohepatitis (8). Here, PLA2G2A is linked to metabolic dysfunction-associated steatotic liver disease.