Other PNPLA enzymes actually exhibit different activities than PLA2, for example, PNPLA3 is actually a triacylglycerol lipase rather than a PLA2, and there is enormous interest in this enzyme currently because of its association with nonalcoholic fatty liver disease and its advanced form nonalcoholic steatohepatitis (8). The gene discussed is PLA2G6; the disease is metabolic dysfunction-associated steatohepatitis.