These proto-oncogenes have been reported to be strongly associated with cell proliferation in studies demonstrating cell proliferation upregulation by forced expression of MAFB [42], tumor cell proliferation by heterodimerization with ERBB2 and ERBB3 [43], expression of BCL2 and BCL6 involved in anti-apoptotic activity [44, 45], and cancer cell proliferation inhibitory effects using shRNAi against CBLC [46]. The gene discussed is ERBB3; the disease is cancer.