An early and accurate diagnosis of DLB is critical because it can lead to early initiation of effective treatment for cognitive and psychiatric disorders, such as acetylcholinesterase inhibitors (AChEIs), and avoidance of potentially life-threatening treatments such as antipsychotic drugs, which are known to increase the risk of serious side effects in patients with DLB [1, 2]. The gene discussed is ACHE; the disease is Lewy body dementia.