Aortic aneurysm rupture model of mice was established by administering β-aminopropionitrile (BAPN), a lysyl oxidase inhibitor, and angiotensin II (Ang II) to induce hypertension and degeneration of the elastic lamina, which would eventually result in the onset of aneurysm rupture. The gene discussed is AGT; the disease is aortic aneurysm.