Although Omicron S protein has been observed to have weaker or comparable binding affinity to ACE2 [59,60], Omicron S protein pseudotyped virus displayed 2.5- and 5-fold higher infection than Delta and D614G pseudotypes, respectively (S9A Fig), suggesting that Omicron exploits different or additional cell entry pathways to replicate in human intestinal organoids. The gene discussed is ACE2; the disease is infection.