MPO and ischemic stroke: Nevertheless, neutrophil-depleted mice had reduced levels of circulating MPO-DNA complexes (112.8% ± 46.6% vs. 231.3% ± 74.8%; Figure 5I) and were protected from ischemic stroke brain injury (47.5 ± 15.8 mm3 vs. 73 ± 19.5 mm3; Figure 5, J and K, and Supplemental Figure 10, C and D).